John F Tisdale Selected Research

Sickle Cell Anemia (Hemoglobin S Disease)

1/2022	Biologic and Clinical Efficacy of LentiGlobin for Sickle Cell Disease.
1/2022	Optimizing haematopoietic stem and progenitor cell apheresis collection from plerixafor-mobilized patients with sickle cell disease.
1/2022	Gene Therapy for Hemoglobinopathies: Beta-Thalassemia, Sickle Cell Disease.
12/2021	CRISPR-Cas9 to induce fetal hemoglobin for the treatment of sickle cell disease.
12/2021	Increased Rates of Rhabdomyolysis in Male Hematopoietic Cell Transplantation Recipients Taking Sirolimus and Trimethoprim/Sulfamethoxazole.
11/2021	Disease severity impacts plerixafor-mobilized stem cell collection in patients with sickle cell disease.
6/2021	Cas9 protein delivery non-integrating lentiviral vectors for gene correction in sickle cell disease.
2/2021	Allogenic hematopoietic stem cell transplantation in sickle cell disease.
1/2021	Sustained fetal hemoglobin induction in vivo is achieved by BCL11A interference and coexpressed truncated erythropoietin receptor.
1/2021	Non-myeloablative human leukocyte antigen-matched related donor transplantation in sickle cell disease: outcomes from three independent centres.

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John F Tisdale Research Topics

Disease

59	Sickle Cell Anemia (Hemoglobin S Disease) 01/2022 - 02/2002
10	Infections 12/2021 - 10/2012
7	Thalassemia 01/2022 - 07/2014
5	Graft vs Host Disease (Graft-Versus-Host Disease) 12/2021 - 07/2014
5	Hemolysis 11/2017 - 01/2009
4	beta-Thalassemia (Cooley's Anemia) 12/2021 - 10/2004
4	Sickle Cell Trait 01/2016 - 02/2002
3	Hemoglobinopathies 12/2021 - 01/2020
3	Severe Combined Immunodeficiency (Bare Lymphocyte Syndrome) 12/2019 - 11/2012
3	Hematologic Neoplasms (Hematological Malignancy) 12/2003 - 01/2002
2	Hypoxia (Hypoxemia) 01/2021 - 09/2007
2	Leukemia 01/2021 - 03/2004
2	Inflammation (Inflammations) 06/2020 - 09/2017
2	Pain (Aches) 01/2019 - 07/2014
2	Anemia 11/2017 - 08/2014
2	Infertility (Sterility) 01/2017 - 09/2014
2	Iron Overload 01/2017 - 09/2014
2	Exanthema (Rash) 07/2011 - 12/2003
2	Pneumonia (Pneumonitis) 12/2009 - 02/2008
2	Neoplasms (Cancer) 09/2008 - 10/2002
2	Aplastic Anemia (Anemia, Hypoplastic) 12/2002 - 09/2002
2	Hodgkin Disease (Hodgkin's Disease) 10/2002 - 01/2002
1	Rhabdomyolysis 12/2021
1	Seizures (Absence Seizure) 12/2021
1	Chronic Pain 11/2021
1	primary familial and congenital Polycythemia 01/2021
1	Diabetes Insipidus 01/2021
1	B-Cell Lymphoma (Lymphoma, B Cell) 01/2021
1	Chronic Granulomatous Disease 12/2020
1	Bacterial Infections (Bacterial Infection) 12/2020
1	Cytomegalovirus Infections (Inclusion Disease) 01/2019
1	Malaria 10/2018
1	Acute Chest Syndrome 02/2018
1	Acute Erythroblastic Leukemia (Erythroleukemia) 01/2018

Drug/Important Bio-Agent (IBA)

18	GlobinsIBA 01/2022 - 01/2006
14	Hemoglobins (Hemoglobin)IBA 01/2022 - 10/2004
9	Fetal Hemoglobin (Hemoglobin F)IBA 12/2021 - 09/2007
6	plerixafor FDA Link 01/2022 - 07/2011
6	Sirolimus (Rapamycin)FDA Link 12/2021 - 02/2008
6	Proteins (Proteins, Gene)FDA Link 01/2021 - 12/2002
6	Granulocyte Colony-Stimulating Factor (G-CSF)IBA 01/2017 - 01/2004
4	Hydroxyurea (Hydrea)FDA LinkGeneric 11/2021 - 01/2015
4	Cyclophosphamide (Cytoxan)FDA LinkGeneric 04/2017 - 09/2002
4	IronIBA 01/2017 - 07/2014
3	Erythropoietin FDA Link 01/2021 - 09/2007
2	Immunosuppressive Agents (Immunosuppressants)IBA 12/2021 - 09/2008
2	Messenger RNA (mRNA)IBA 01/2021 - 12/2020
2	AntibodiesIBA 07/2020 - 11/2017
2	BilirubinIBA 09/2017 - 01/2009
2	Alemtuzumab (Campath)FDA Link 04/2017 - 09/2014
2	Immunologic Factors (Immunomodulators)IBA 02/2014 - 09/2013
1	SolutionsIBA 01/2022
1	Citric Acid (Citrate)FDA LinkGeneric 01/2022
1	AnticoagulantsIBA 01/2022
1	Biological ProductsIBA 01/2022
1	Glucose (Dextrose)FDA LinkGeneric 01/2022
1	3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA)IBA 12/2021
1	Acyclovir (Aciclovir)FDA LinkGeneric 12/2021
1	Anti-Infective Agents (Microbicides)IBA 12/2021
1	Creatine Kinase (Creatine Phosphokinase)IBA 12/2021
1	Sulfamethoxazole Drug Combination Trimethoprim (Co-Trimoxazole)FDA LinkGeneric 12/2021
1	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 12/2021
1	CRISPR-Associated Protein 9IBA 06/2021
1	Dietary IronIBA 01/2021
1	Erythropoietin Receptors (Erythropoietin Receptor)IBA 01/2021
1	Glycated Hemoglobin (Glycosylated Hemoglobin)IBA 01/2021
1	MicroRNAs (MicroRNA)IBA 01/2021
1	Small Interfering RNA (siRNA)IBA 01/2021
1	CytokinesIBA 01/2021
1	HLA Antigens (Human Leukocyte Antigens)IBA 01/2021
1	Arginine Vasopressin (Argipressin)IBA 01/2021
1	Anti-Bacterial Agents (Antibiotics)IBA 12/2020
1	NADP (NADPH)IBA 12/2020
1	NADPH Oxidases (NAD(P)H oxidase)IBA 12/2020
1	RNA (Ribonucleic Acid)IBA 06/2020
1	Interleukin Receptor Common gamma SubunitIBA 12/2019
1	Busulfan (Busulfex)FDA Link 12/2019
1	RibonucleoproteinsIBA 11/2019
1	DNA (Deoxyribonucleic Acid)IBA 11/2019
1	CRISPR-Cas Systems Guide RNAIBA 11/2019
1	SteroidsIBA 01/2019
1	Adrenal Cortex Hormones (Corticosteroids)IBA 01/2019
1	Opioid Analgesics (Opioids)IBA 01/2019
1	Nucleic AcidsIBA 10/2018
1	Vasopressins (Vasopressin)IBA 11/2017

Therapy/Procedure

17	Transplantation 12/2021 - 01/2002
10	Hematopoietic Stem Cell Transplantation 01/2022 - 07/2009
10	Therapeutics 09/2021 - 12/2002
6	Homologous Transplantation 01/2020 - 01/2002
5	Blood Component Removal (Apheresis) 01/2022 - 02/2002
4	Cell Transplantation 12/2021 - 01/2019
2	Stem Cell Transplantation 01/2018 - 12/2009
2	Hematopoietic Stem Cell Mobilization 01/2018 - 02/2002
2	Drug Therapy (Chemotherapy) 11/2017 - 01/2009
2	Peripheral Blood Stem Cell Transplantation (Peripheral Stem Cell Transplantation) 04/2017 - 03/2017
2	Bone Marrow Transplantation (Transplantation, Bone Marrow) 03/2017 - 06/2005
1	Autologous Transplantation 01/2022
1	Transcutaneous Electric Nerve Stimulation (TENS) 09/2021
1	Duration of Therapy 01/2019
1	Aftercare (After-Treatment) 10/2018